Skin cancer Essay Example for Free

Skin cancer Essay How many of you have every laid out in the sun on purpose just to get a tan?   Or better yet how many of you believe you look prettier or more handsome tan?   According to the American Cancer Society more than 1 million people are diagnosed with skin cancer each year and the numbers seem to be increasing day to day. And believe it or not skin cancer is the most common of all cancers.   Today I am going to inform you about skin cancer and how you can protect yourself from it. To begin, our skin is the largest organ of the body and it covers our internal organs and protects them from injury.   The skin also serves as a barrier between germs and our internal organs.   Our skin regulates body temperature and helps the body get rid of excess waste.   Certain cells in our skin also communicate with the brain and allow us the feel temperature, touch, and pain sensations. Some may ask, what exactly is skin cancer and why is it such a big deal now?   Well there are two basic types of skin cancer; Nonmelanoma (which is also called basal or squamous cell) skin cancer and then there is melanoma skin cancer. Most skin cancers are classified under nonmelanoma, meaning that the cells are located at the base of the outer, layer of the skin.   Basically, the skin that covers the surface of the body, not the deep tissues.   Nonmelanoma skin cancer usually develops on sun-exposed areas of the body, places like: the face, ears, necks, lips, and the backs of hands.   Depending on the type they can be fast or slow growing but rarely spreads to other parts of the body.   There is a cure for nonmelanoma skin cancer is detected and treated early. On the other hand, you have melanoma skin cancer.   Which is the more dangerous of the two; however it is also the least common.   Melanoma skin cancer tends to spread very quickly to other body parts.   However, it is almost always curable if it is detected in the early stages.   But the killer part is a lot of people do not realize that they may have melanoma skin cancer until the later stages, after it has already started affecting other organs.   Once it has reached that stage, it is virtually incurable.   People diagnosed with melanoma skin cancer that has already spread to other body parts are given on average a five year survival rate. So what puts you at risk for skin cancer?   Some high risk factors include:  · Unprotected and/or excessive exposure to Ultraviolet(uv) radiation  · Fair complexions( people with red hair, most likely)  · Occupational exposures (i.e. Construction workers, arsenic compounders, baseball players)  · Family history of skin cancer  · Multiple or atypical moles  · Severe sunburns as a child So how can you detect skin cancer? Some signs of skin cancer in the early stages may include but are not limited:  · any change on the skin, especially in the size or color of a mole or other darkly pigmented growth or spot, or a new growth  · scaliness, oozing, bleeding, or change in the appearance of a bump or nodule  · the spread of pigmentation beyond its border such as dark coloring that spreads past the edge of a mole or mark  · a change in sensation, itchiness, tenderness, or pain in a mole

Water Soluble Vitamins for Poultry

Water Soluble Vitamins for Poultry The vitamins are a very important class of the nutrients. They play various important roles in the life cycle of any living-being. The absence or deficiency of the vitamins in poultry causes serious problems. The water soluble vitamins are very important sub-class of vitamins. In the poultry which can not synthesize these vitamins in their body these should be provided in the diets means these are dietary essential. The inclusion of the water soluble vitamins accurately, according to the needs of birds, production stage, physiological state of the birds and environmental conditions is very necessary to avoid the problems and to gain maximum performance because these vitamins are required by the birds in many systems including energy metabolism, growth, proper blood flow, development of skeleton, compensation of the stress, egg production, fertility, anti-oxidants for semen and proper development and viability of the growing embryos. It means these are not only important for current b irds but also their provision in an accurate way will ensure the next generation of the birds. Key words: roles, water soluble vitamins, poultry. Introduction The term vitamin was first used in 1912. Vitamins are a group of complex organic compounds which are present in minute amounts in natural feedstuffs. These are required for normal metabolism and the deficiency of these compounds in the feed causes deficiency diseases. The vitamins are divided into two groups depending upon their solubility i.e. Fat soluble vitamins which include Vitamin A, D, E and K. Water soluble vitamins which are Vitamin B-complex and vitamin C. The names, synonyms and the two classes i.e. fat and water soluble can be summarized as: Vitamin names Synonyms Fat soluble Vitamin A1 Retinol, retinal, retinoic acid Vitamin A2 Dehydroretinol Vitamin D2 Ergocalciferol Vitamin D3 Cholecalciferol Vitamin E Tocopherol, tocotrienols Vitamin K1 Phylloquinone Vitamin K2 Menaquinone Vitamin K3 Menadione Water soluble Thiamin Vitamin B1 Riboflavin Vitamin B2 Niacin Vitamin PP, Vitamin B3 Vitamin B6 Pyridoxol, pyridoxal, pyridoxamine Pantothenic acid Vitamin B5 Biotin Vitamin H, vitamin B8 Folic acid Folacin, folate, Vitamin M, Vitamin Bc, Vitamin B9 Vitamin B12 Cobalamin Choline Gossypine Vitamin C Ascorbic acid (Adopted from McDowell, 2004) Poultry and other monogastric animals are dependent on dietary sources of vitamins to a much greater degree than are ruminants. It is considered that animals with fully functional rumen can not suffer from a deficiency of vitamin B-complex. Vitamin B12 is unique in that it occurs in plant tissues as a result of microbial synthesis (McDowell, 2004). Thiamin (B1) is required to control appetite and reduces death rate, Riboflavin (B2) is responsible to control curly-toe paralysis, proper growth and proper egg production, Pantothenic acid(B5) is necessary for controlling dermatitis and improper lesions on the mouth and feet, Niacin (B3) is involved in proper confirmation of legs, tongue and mouth cavity, Choline ensures proper growth and proper egg production, Vitamin B12 is required to control anemia and to control early embryonic death, Folic acid (B9) is required for proper growth, controlling of anemia, proper feathering and proper egg production, Biotin (B8) is required to control d ermatitis o feet, around eyes and beak and Ascorbic acid(vitamin C) is required to normal growth and development, growth and repair of tissues, formation of collagen, cartilage, bones, avoid stresses and wound healing (Unknown, 2002). Vitamin C (vit C) is a water soluble antioxidant found in cytosol and extracellular fluids and it can directly scavenge super oxide hydroxyl radicals and single oxygen species (Clarkson and Thompson, 2000). It is thought to exert its effects on the immune system through the enhancement of neutrophil production and through protection of the cell against super oxide radical damage (Bendich et al., 1986). Under normal conditions birds can synthesize sufficient amounts of vit C (Roy and Guha, 1958), however in the stress conditions birds may require an external source of vit C (Meade S.M. 2004) to provide non-specific resistance against infections and overcome stress and therefore improving productivity (Pardue and Thaxton, 1985). The phagocyte activity is enhanced in the presence of vit C. There is a higher quantity of the superoxides found in the phagocytes when sufficient amounts of vit C are found and further increase in the level of vit C further increases the amount of free radicals in phagocytes (Scarpa et al., 1983; Som et al., 1983). Viral infections have been shown to cause a depletion of leukocyte ascorbate, which resulted in varying degrees of non-specific immunosuppression and a reduction in serum vit C concentration (Thomas and Holt, 1978; Bendich et al., 1986). The role of vit C in controlling of stress has been documented many a times. There was a proof that by providing external vit C source at a rate of 330ppm the blood levels of vit C are elevated (Nestor et al., 1972). Another study showed that a 1000ppm adding of vit C reduces exogenous cortisol related immunosuppression. Some studies have also reported that vit C decreases heat shock protein 70 and plasma corticosterone response in chicken subjected to cyclic heat stress (Mahmoud et al., 2003, 2004). Vitamin C supplementation in feed or water can also reduce the sensation of fear in the birds (Jones, R. B., 1996). Pardue and Thaxton (1986) documented the effects of supplementation with vit C on a number of characteristics including growth, reproductive performance, immunosuppression and mortality. It was also documented by Satterlee et al., 1989; Kutlu and Forbes, 1993a; McKee and Harrison, 1995) Poultry under intensive production systems are particularly susceptible to vit deficiencies so to avoid this poultry feeds are supplemented normally with B2, niacin, pantothenic acid, B12 and choline out of water soluble vitamins (Scott et all. 1982). It is to be noted that Thiamin, vitamin B6, biotin and folacin are mostly present in adequate quantities in the major ingredients such as corn-soybean meal-based diets and poultry can normally produce a sufficient amount of ascorbic acid by its own (McDowell, L. R. 2004). Vitamin needs of new strains developed for improved production are higher. Leg problems seen in fast growing strains of broilers can be corrected in part by higher levels of biotin, folacin, niacin and choline (Roche 1979). Stress and disease conditions in animals may increase the basic requirement for certain vitamins. Nutrient levels that are adequate for growth, feed efficiency, gestation and lactation may not be adequate for normal immunity and for maximizing the a nimals resistance to disease (Cunha 1985; Nockels et al. 1996). Diseases and microorganisms affecting the gastro intestinal tract reduce the absorption as well as the production of vitamins also the conditions affecting the G.I.T. cause a reduction in vitamin production and absorption i.e. diarrhea and vomiting (McDowell, L.R., 2004). Mycotoxins and internal bleeding in poultry also causes a reduced efficiency of vitamins (McDowell, L.R., 2004). Vitamin antagonists (antimetabolites) interfere with the activity of various vitamins (Oldsfield, 1987). Under commercial production a higher level of the vitamins is helpful for optimum production and performance this also helps in achieving best growth rates, feed utilization and health and in part also helps to increase body reserves (Coelho, 1996). The ascorbic acid acts as an antioxidant for the avian spermatozoa (Surai et all, 2001). Ascorbic acid supplementation enhances the ejaculation qualities of male fowl (Surai et all, 2001). In the hot and dry season offering the cold water supplemented with ascorbic acid increases weight gain and spleen but it will also cause a reduced size of wings (Abioja, et all, 2011). Classes of B-Complex Based on the functions the B-complex can be categorized into 3 classes, however some of the members fall into more than one class; Energy releasing Thiamine (B1), Riboflavin (B2), Niacin (B3), Pantothenic acid (B5), Piroxidine (B6), and Biotin. Hematopoietic Folic acid (B9), Cyanocobalamin (B12), Pantothenic acid (B5), and Piroxidine (B6). Other Thiamine (B1), Niacin (B3), Piroxidine (B6), Folic acid (B9), and Cyanocobalamin (B12). (Wilson, G. V.) Vitamin B-complex deficiencies Deficiency arises due to inadequate supplies of the vitamins and the signs develop over a time period. So if the vitamin levels provided are lower than the required levels then the classical deficiency signs will be seen in the birds. Generally the young and growing chicks are more prone to vitamin deficiencies and the developing embryo is the best model showing deficiencies of vitamins. Problems due to the B-complex deficiency arise quite abruptly and often seen in 5-7 days because there is a little storage of these in the body (Leeson, S. and J. D. Summers, 2001). In the researches carried out on poultry of different age groups it was shown that a deficiency in the availability of Thiamine (B1) caused a loss of appetite and increased death ratios (Poultry Health Services, 2009). Leeson, S. and J. D. Summers, 2001 stated that polyneuritis in the birds shows the later stages of thiamine deficiency which may arise due to the build up of the intermediates of carbohydrate metabolism. In mature birds it is seen approximately 3 weeks after they are being fed a thiamine deficient feed. Poultry may also suffer from neuromuscular problems, resulting in impaired digestion, general weakness, star gazing and frequent convulsions (Leeson, S. and J. D. Summers, 2001). A deficiency in the availability of Riboflavin (B2) caused increased occurrence in the curly toe paralysis, poor growth and poor egg production (Poultry Health Services, 2009). Many tissues especially epithelium and myelin sheath are affected due to feeding of a feed which is d4eficient in riboflavin and on postmortem the characteristic sign of riboflavin deficiency is marked enlargement of the sciatic and brachial nerve sheath with the sciatic nerve showing the most pronounced effects (Leeson, S. and J. D. Summers, 2001). A feeding programme with a deficient amount of Pantothenic acid (B5) is evident as occurrence of dermatitis and lesions on mouth and feet (Poultry Health Services, 2009). According to Leeson, S. and J. D. Summers, 2001 the major lesions due to deficiency of pantothenic acid involve nervous system, the adrenal cortex and the skin. Niacin (B3) deficiency is shown by bowed legs and inflammation of tongue and mouth cavity (Poultry Health Services, 2009). Leeson, S. and J. D. Summers, 2001 report that niacin deficiency is characterized by severe metabolic disorders of skin and digestive organs, signs being the loss of appetite, retarded growth, general weakness and diarrhea in the birds. A feeding programme having deficiency of pyridoxine (B6) is characterized by retarded growth, dermatitis, convulsions, anemia and there may also be reduced nitrogen retention (Leeson, S. and J. D. Summers, 2001). Choline deficiency is evident from poor growth, fatty liver, decreased egg production (Poultry Health Services, 2009). Leeson, S. and J. D. Summers, 2001 report the deficiency of choline in growing chicks is evident from poor growth and perosis. Cobalamin (B12) deficiency is shown by cases of anaemia, poor growth, embryonic mortality (Poultry Health Services, 2009). According to Leeson, S. and J. D. Summers, 2001 a deficiency of B12 in growing chicks showed decreased weight gain, decreased feed intake, poor feathering and poor nervous system. Folic acid (B9) deficiency is evident from poor growth, anaemia, poor feathering and poor egg production (Poultry Health Services, 2009). A deficiency of folic acid in the experimental birds caused macrocytic (megaloblastic) anemia and leukopenia i.e. reduced white blood cells (Leeson, S. and J. D. Summers, 2001). Biotin (B8) deficiency increases the dermatitis on feet and skin around eyes and beak (Unknown, 2004; Poultry Health Services, 2009; Roche 1979; Leeson, S. and J. D. Summers, 2001). The diseases and problem seen due to deficiencies of the water soluble vitamins in poultry can be summarized in the following table Deficient vitamin: Thiamine (B1) Evident deficiency signs: loss of appetite increased death ratios polyneuritis impaired digestion general weakness star gazing frequent convulsions Deficient vitamin:  Riboflavin (B2) Evident deficiency signs: curly toe paralysis poor growth poor egg production affected epithelium and myelin sheath Deficient vitamin:  Pantothenic acid (B5) Evident deficiency signs: dermatitis lesions on mouth and feet Deficient vitamin:  Niacin (B3) Evident deficiency signs: bowed legs inflammation of tongue and mouth cavity Loss of appetite retarded growth general weakness diarrhea Deficient vitamin:  pyridoxine (B6) Evident deficiency signs: retarded growth dermatitis convulsions anemia Choline poor growth fatty liver decreased egg production perosis Deficient vitamin:  Cobalamin (B12) Evident deficiency signs: anaemia poor growth embryonic mortality Decreased weight gain decreased feed intake poor feathering Poor nervous system. Deficient vitamin:  Folic acid (B9) Evident deficiency signs: poor growth anaemia poor feathering poor egg production leukopenia Deficient vitamin:  Biotin (B8) Evident deficiency signs: dermatitis on feet and skin around eyes and beak (Poultry Health Services, 2009; Roche 1979; Leeson, S. and J. D. Summers, 2001) Role of water soluble vitamins as Co-enzymes Riboflavin or vitamin B2 is a prosthetic part of over a dozen enzymes in the animal body including cytochromes reductase, lipoamide dehydrogenase, xanthine oxidase, L- and d-amino acid oxidase, histaminase and others all of which are vital for oxidation-reduction reactions involved in cell respiration (Leeson, S. and J. D. Summers, 2001). Niacin or nicotinic acid is important in more than 100 different enzymatic reactions (Rasmusson R.) It is the vitamin component in two important enzymes i.e. nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) reported by Leeson, S. and J. D. Summers, 2001. Pantothenic acid (B5) is the prosthetic group of coenzyme A, an important coenzyme involved in many reversible acetylation reactions in carbohydrate, fat and amino acid metabolism (Leeson, S. and J. D. Summers, 2001). Biotin (B8) is an essential co-enzyme in carbohydrate, fat and protein metabolism (Leeson, S. and J. D. Summers, 2001). Vitamin B12 is an essential part of several enzyme systems, with most reactions involving the synthesis of one carbon units i.e. methyl groups (Leeson, S. and J. D. Summers, 2001). Role of Ascorbic acid (vitamin C) in birds under stressful conditions The efficacy of supplementing birds with vitamin C under stressful conditions depends upon its ability to elevate plasma vitamin C (Pardue et al., 1984). Nestor et al., (1972) reported that 330ppm vitamin C elevated blood vitamin C. Pardue et al., (1984) reported that vitamin C supplementation at a rate of 250ppm increased plasma vitamin C concentrations in broilers. But Sell et all in 1997 found that 300 mg/kg vitamin C was unable to increase plasma vitamin C levels. Kolb (1984) strongly suggested that supplemental vitamin C should be provided in poultry and livestock diets as a stress alleviator. Hill and Garren (1958) agreed and stated that vitamin C was an essential nutrient in chickens experiencing stress. Vitamin C supplementation at 300 mg/kg was able to decrease plasma corticosterone in stressed birds. These responses are supported by research suggesting that vitamin C suppresses adrenocortical steroidogenesis and depresses plasma corticosterone levels, therefore limiting som e of the deleterious responses associated with stress and delays the depletion of steroid hormone precursors (Pardue et al., 1985; Gross, 1992; Kutlu and Forbes, 1993). The action of vitamin C on adrenal steroidogenesis is associated with its ability to inhibit adrenal steroid hydroxylating enzymes (Kitabchi, 1967). Supplementation with 300 mg/kg of ascorbic acid resulted in a significant increase in plasma vitamin C throughout the experiment when compared to the Un-Supplemented birds (Meade, S.M., 2004). There is limited research examining the effects of vitamin C on lymphocyte subset populations in chickens. However, those experiments that have been demonstrated the effects of vitamin C on lymphocyte populations in association with disease or vaccination (Wu et al., 2000). The effect of dietary vitamin C supplementation is still controversial however vitamin C supplementation at 300 mg/kg alleviated stress-induced affects (Meade, S.M., 2004). These physiological and immunological findings suggest that vitamin C may be an anti-stress agent and may be an essential nutrient in poultry when poults are subjected to stressful conditions (Meade, S.M., 2004). Ascorbic acid as an anti oxidant for avian spermatozoa Ascorbic acid or vitamin c is water soluble anti oxidant present at high molar concentrations in spermatozoa and seminal plasma in a large number of animals. In poultry its concentration in semen averages 210 +-16.4microM (Surai et all 1986b). On a molar basis this concentration was more than 2.5 times higher than glutathione and more than 100 fold higher than alpha-tocopherol. Ascorbic acid was found almost equally distributed between spermatozoa and seminal plasma (Surai et all 1986b). This data was very useful in the development of an idea that vit. C plays an important role as a water soluble anti oxidant in the avian seminal plasma (Surai et all, 2001). Ascorbic acid effect on ejaculation quality of male Fowl Monsi and Onitchi in 1991 reported that fowl males housed under hot and humid conditions and supplemented with ascorbic acid showed a better overall ejaculation quality i.e. semen volume, motile sperm proportion and sperm number per ejaculate. The reported ascorbic acid supplementation level was 500mg/kg. However sperm motility was not affected. Dietary supplementations of ascorbic acid had the effects on semen of rainbow trout reflected by increased sperm motility and decreased decline in fertilizing capacity of spermatozoa after storage (Ciereszko and Dabrowski, 2000). A protective role of ascorbic acid in maintaining the sperm quality was also reported by Ciereszko and Dabrowski in 1996. However the low dietary levels of vitamin E and C (ascorbic acid) had no effects on the spermatozoa in mice rather the increased and higher supplementary levels decreased the number of spermatozoa/mg epididymis and increased the percentage of spermatozoa with misshapen heads (Ten et all, 1997). Role of ascorbic acid in weight gain A study was carried out in SW Nigeria on a group of broiler chicken. The birds were divided into four groups after the age of three weeks. A group was given cold water without any ascorbic acid and other group was given cold water with supplementation of ascorbic acid. Similarly two groups were made for normal unchilled water with and without ascorbic acid provision. The results of study showed a marked superior growth of breast meat and spleen in the group provided with cold water and ascorbic acid. However there was no affect of ascorbic acid supplementation on the growth parameters of the birds in any of the four groups. In addition there was a decreased wing length seen in these birds. The reason for this phenomenon to happen is that in hot climatic conditions a lot of the energy is wasted in panting and when cold water is provided the birds feel comfort and there is less panting seen. Also in stress corticosteroids are released which further decrease the weight gain. By providin g cold water these both conditions are avoided so better results are obtained. The cold water resulted in an overall more weight gain weekly and finally more live weight however decreased wing length, the vitamin c had no effect on the growth however it increased the breast meat and the spleen in birds, (Abioja, et all, 2011). Role of water soluble vitamins in Energy metabolism The transformation of dietary energy sources, such as carbohydrates, fats and proteins into cellular energy in the form of ATP requires several micronutrients as coenzymes and cofactors of enzymatic reactions, as structural components of enzymes and mitochondrial cytochromes, and as active electron and proton carriers in the ATP-generating respiratory chain(Groff et all, 1996, Depeint et all, 2006): (i) thiamine pyrophosphate (TPP; vitamin B1), CoA (containing pantothenic acid), flavin mononucleotide (FMN; derived from vitamin B2), flavin adenine dinucleotide (FAD; derived from vitamin B2) and nicotinamide adenine dinucleotide (NAD; derived from nicotinamide) are involved in the Krebs cycle and complexes I and II of the respiratory chain; (ii) biotin, CoA and FAD are involved in haem biosynthesis, which is an essential part of the cytochromes and important for the latter part of the mitochondrial respiratory chain; (iii) succinyl-CoA can feed into either the respiratory chain or the Krebs cycle depending on the needs of the cell. Depeint et all, in 2006 confirmed the essential role of vitamins B6, B12 and folate in maintaining the mitochondrial one-carbon transfer cycles by regulating mitochondrial enzymes. The same authors also emphasized the essential role of the B vitamin family in maintaining mitochondrial energy metabolism and how mitochondria in their role as the cellular organelles responsible for energy metabolism are compromised by a deficiency of any B vitamin (Depeint et all, 2006). Table given here summarizes the present state of knowledge with regard to the role or roles of individual water soluble vitamins in energy metabolism (adopted from Institute of medicine, 1998). Vitamins Function in energy metabolism Thiamine (B1) Essential cofactor in the conversion of carbohydrates to energy. Needed for normal muscle function, including the heart muscle. Involved in oxidative carboxylation reactions, which also require manganese ions. Riboflavin (B2) As a cofactor in the mitochondrial respiratory chain, helps in the release of energy from foods. Component of the main coenzymes FAD and FMN. Nicotinic acid, niacin (B3) As a cofactor in the mitochondrial respiratory chain, helps in the release of energy from foods. Transformed into NAD and NADP, which play a key role in oxidation -reduction reactions in all cells. Pyridoxine (B6) Helps in the release of energy from foods. Used as a cofactor by nearly 100 enzymatic reactions, mainly in protein and amino acid metabolism. Vitamin B12 Essential for metabolism of fats and carbohydrates and the synthesis of proteins. Interacts with folic acid metabolism. Biotin As a cofactor, involved in metabolism of fatty acids, amino acids and utilization of B vitamins. Pantothenic acid Plays an essential role in the Krebs cycle. Component of coenzyme A. Vitamin C Essential for synthesis of carnitine (transports long-chain fatty acids into  (Ascorbic acid) mitochondria) and the catecholamines, adrenaline and noradrenaline. Ascorbic acid facilitates transport and uptake of non-haem iron at the mucosa, the reduction of folic acid intermediates, and the synthesis of cortisol. Potent antioxidant. Folic acid Folates function as a family of cofactors that carry one-carbon (C1) units required for the synthesis of thymidylate, purines and methionine, and required for other methylation reactions. Folate is essential for metabolic pathways involving cell growth, replication and survival of cells in culture. Around 30 50% of cellular folates are located in the mitochondria. Toxicity arising due to water soluble vitamins Toxicities arise due to over supplementation levels or more inclusion rates of the nutrients. Generally the toxicity of the water soluble vitamins is not seen in the birds because of the reason that these vitamins have a very minimal storage in the body. If the inclusion rate of vitamin B-complex is at least 100x than the required level, it tends to cause toxicity in the poultry. Vitamin C, E and Biotin are moderately toxic, potentially causing problems at 20-30x the normal inclusion levels. Toxicity of vitamins administered in the drinking water is quite rare because the birds are reluctant to drink such fortified water (Leeson, S. and J. D. Summers, 2001). Conclusion From above discussion it can be concluded that the water soluble vitamins play many important roles in the poultry life including proper growth, production, weight gain, egg production, immunity, proper conformity, proper functioning, avoiding of stress due to many origins, proper feathering, proper skin condition and proper embryo development. The water soluble vitamins are required in the metabolism, in the oxidation and reduction reactions as coenzymes which mean these are vital for the survival of the animals. These also enhance the quality of the ejaculation in male fowl as well a act as antioxidants for the avian spermatozoa ensuring the fertility and avoiding deformities in the semen of poultry. The water soluble vitamin family member, ascorbic acid is also involved in extra gain of the breast meat which is most liked part of chicken meat in general.

Relationship Between Obesity and Socioeconomic Demographics

Relationship Between Obesity and Socioeconomic Demographics Chapter Five: Discussion The prevalence as well as the severity of obesity in adolescents is increasing at an alarming rate, making it one of the most serious health problems affecting this age group. In this study, a total of 161 adolescents (15.6%) were overweight and 224 ones(21.6%) were obese. A study conducted by National Health and Nutrition Examination Survey (NHANES 1999-2000) showed thatapproximately 30% of adolescents were at risk for overweight and 14% were severely overweight or obese (Troiano and Flegal, 1999). In this study, the prevalence of overfat was 9.1% and obesity was 21.8%. A study conducted by Lee ea al. (2006) showed thatthe prevalence of total 555 adolescentboys were overfat (20.4%) and 8.3% were obese. In our study, prevalence of obese adolescents, according to both BMI and total fat, was higher than overweight;this could be attributed to high rate of fast food consumption among adolescents 72%. Fraser et al. (2012) conducted a study in the United Kingdom and observed anassociation between obese adolescents and fat food consumption. The prevalence of waist circumferences≠¥90th percentile in this study was 9.4%. This is consistent with Spain’s result, prevalence of waist circumferences≠¥90th percentile among adolescents was 11.6% (Schr à ¶der et al., 2014). Association between anthropometric measurements and socio-demographic characteristics: In our study, the BMI was significantly related to family income (p=0.004). About 25.7% of obese adolescents had families whose income was >800 JD after adjusting variables effects of results including age, smoking and physical activity. Shafaghiet al. (2014) studied the relationship between BMI and family income, 22.4% of obese adolescents were from families whose income was high. Total fat was significantly associated with adolescents age (p= 0.027). Adolescents aged ≠¥12 and ≠¤14 years old were more predictable to have high fat percentage (25.6%) than adolescents aged ≠¥ 15 and ≠¤17 years (18.9%).This finding was consistent with Northstoneet al. (2014). In our study, total fat was related to family income significantly (p=0.022). Kubiket al. (2003) conducted a study of 844 students; the study showed that students with high family income tended to consume sweetened beverages and high-fat snacks. Region affected significantly total fat among adolescents (p=0.049). The prevalence of obese adolescents were higher in middle area than north and south areas; that could be attributed to high fast food intake in middle area (48.2%) comparing to north and south areas (35.3% and 16.6%respectively). Limited data to explain relation between body fat content with father’s and mother’s education. Trunk fat was significantly associated with adolescents age (p= 0.027). Adolescents aged ≠¥12 and ≠¤14 years old were more predictable to have high trunk fat (15.4%) than adolescents aged ≠¥ 15 and ≠¤17 years (10.8%). Fox et al. (2000) reported thatadolescents aged 11- 13 years were associated with high trunk fat using magnetic resonance imaging (MRI). Association between blood pressure and socio-demographic characteristics: Blood pressure was significantly related to adolescents’ age (p0.01).This relation showed that 35.7% of adolescents aged ≠¥ 15 and ≠¤17 years had stage 2 HT compared to only 20.3% among adolescents aged ≠¥12 and ≠¤14 years old had stage 2 HT. Mouraet al. (2004) concluded a study on 898 adolescents,prevalence of elevated blood pressure in students aged ≠¥ 15 and ≠¤17 years was more than students aged ≠¥12 and ≠¤14 years. Effect of food categories on the prevalence of blood pressure among adolescents: Fruit and vegetables consumption were significantly related to blood pressure (p=0.008 and p=0.033 respectively). This finding was consistent with the findings of studies (Whelton et al., 1997, Whelton et al., 2005, Appel et al., 2006, Witham et al., 2009). Apple et al. (2006) studied the contents offruit and vegetables from vitamins, minerals and fibers. Fruits and vegetablesalso contained potassium;their increase in potassium intake was associated with significantly reduction in blood pressure. The increase in potassium intake had same lowering effect on blood pressure as decrease in sodium intake. Potassium had a major role in balancing out the negative effects of sodium. Wheltonet al. (1997) recommended potassium for prevention and treatment of hypertension. Increasing serum levels of vitamins A, C, E (Appel et al., 2006)and D (Witham et al., 2009)were associated with lowering blood pressure. Meta-analysis suggested that increasing the dietary fiber intake had a lowering effect o n blood pressure (Whelton et al., 2005).According to this study, chocolate was significantly related to blood pressure (p=0.013). Studies explained chocolate’s role to lower blood pressure (Fisher and Hollenberg, 2006, Karim et al., 2000, Taubert et al., 2007). Chocolate contained cocoa that include polyphenols specially flavanols. Strong effects of flavnols on blood pressure as a vasodilator were applied by increasing the formation of endothelial nitric oxide. Families’ health status effect on adolescent’s blood pressure: Father’s and mother’s health status was significantly associated with blood pressure in adolescent (p=0.002, p=0.022 respectively). Many studies (Din-Dzietham et al., 2007, Dasgupta et al., 2006, Martin et al., 2004) confirmed that family history of hypertension and cardiovascular disease were risk factors for elevated blood pressure among adolescents. Family history of obesity including fathers’ and siblings’ obesity was significant with adolescents’blood pressure (p=0.004 and p=0.048respectively).Falkner.(2010) reported a positive relation between blood pressure among adolescents and family history of obesity. Association between blood pressure and anthropometric measurements: Alton. (2005) considered hypertension one of obesity risk factors. Lu et al. (2013) conducted a study in China, and found out that the risk of elevated blood pressure prevalence was 1.5 folds in overweight children and was 2.2 folds in obese children. High BMI increased the risk of insulin resistance. Endothelial dysfunction and inflammation led to elevated blood pressure mediated bythe increase sympathetic nervous system (SNS) activity (Tsioufis et al., 2011, Poirier et al., 2006). Our findings confirmed previous findings of high odds of stage 1 systolic hypertension among overweight adolescents 1.8 folds and 2.7 folds in obese adolescents, adjusting for confounding variables -age, smoking status and physical activity. Our result observed that adolescents with waist circumferences ≠¥90th percentile proportionally related to increase in blood pressure.Lu et al. (2013) reported a high significant association (p Increase in total body fat in our study was significant with increase in blood pressure proportionally. Pre-HTN, stage 1 HTN and stage 2 HTN were significant (p=0.009,p=0.004 and pet al. (2002)used DEXA and skinfolds to estimate total body fat and it’s relation asa predictor for blood pressure among adolescentboys unlike girls. Landsberg et al. (2013) explained that pathophysiology of fat accumulation in abdominal region led to an increase in blood pressure by increases in insulin secretion, (SNS) activity, renin-angiotensin-aldosterone system activity, angiotensinogen from intra-abdominal adipocytes, aldosterone production and renal sodium reabsorption. Our findings confirmed previous findings of high odds of stage1 systolic hypertension among adolescents with trunk fat ≠¥90th percentile had 4 times higher odds of having stage 1 systolic hypertension (CI 2.2, 7.1) and 5.5 higher odds of having stage 2 systolic hypertension (CI 3.4, 9.1). An association between adolescents visceral fat with blood pressure was observed among boys contrary girls (Pausova et al., 2012).Matsuzawa et al.(1995) explained increase that the in visceral fat to induce high level of free fatty acid excretion in liver via portal circulation after lipogenesis and lipolysis activity, gluconeogenesis, lipid synthesis and insulin resistance were response actions causedby excusive free fatty acid to induce hypertension and eventually atherosclerosis.Our results confirmed previous findings of high odds of stage 2 systolic hypertension among adolescents with visceral fat ≠¥90th percentile by 7.2 folds. Conclusion: The prevalence of total, truncal and visceral fat in our study were high. Excessfat,especially visceral fat significantly increased the risk for systolic blood pressure individually in older adolescents. The physiological relation between obesity and hypertension could not be attributed to a single factor. Factors that minimized the activity of renin-angiotensin-aldosterone system, sympathetic nervous system and renal sodium excretion had to be controlled, primarily the factors caused by excess fat. This finding based on measures of fat distribution and blood pressure in adolescent boys is important to help tracks cardiovascular risks from adolescence to adulthood. Strength of the Study This research has been conducted for the first time in Jordan to explain the prevalence and relationship between adolescents’ blood pressure and fat distribution. The study depends on data collected from a large sample that is representative to Jordan as a whole. Limitation of the Study An addition of a 24-hour recall form with this study combined with study’s FFQ could be more precise to estimate dietary and lifestyle habits among adolescents. Recommendations: Serious policies and actions for the sake of prevention, control weight and body fat specially as risks for elevated blood pressure, should be taken to apply an appropriate intervention on affected adolescents. Raise the schools’ role is for mass public enlightenment and health education on the threats of some nutritional behavior and lifestyle.

The Childlike and Biblical Connotations in The Lion, the Witch and the

The Childlike and Biblical Connotations in The Lion, the Witch and the Wardrobe       Throughout his writing career, CS Lewis has been known for writing many books with a hint of biblical connotations in them. As Kathryn Lindskoog states, "CS Lewis is known for opposing the spirit of modern thought with the unpopular Christian doctrines of sin and evil" (2083). Lewis himself has said, "You never know how much you really believe anything until its truth or falsehood becomes a matter of life or death to you" (Freaks 60). Although his belief in God has not yet presented itself in that manner, he continues to devote his time to the artful presentation of what he believes to be true about God and man, as observed by Dr. Bruce Lockerbie (177). The second book in the Narnia Series, The Lion, the Witch and the Wardrobe is no exception. In The Lion, the Witch and the Wardrobe, CS Lewis uses the vehicle of a children's fantasy novel to present latent Christian theology and beliefs.    Children who read the Narnia Series do so for the action and excitement. Authorities say that they are likely to accept the actions and ideas without doubts of how real the story may be (Who's Who 29). Lewis uses childlike images to create deeper meanings than what might otherwise be accessible. One of the most noticeable is the fact that throughout the Narnia Series, the use of children as the main characters establishes a physical connection with young reader. When the main characters grow older, they are told they are not to come back. In Prince Caspian, after the children have helped to defeat Miraz, Aslan warns Peter that he and Susan are too old to enter Narnia again (236). Lewis keeps the main characters young, keeping t... ...m. Ed. James P. Draper. Vol. 4. Detriot: Gale. 1992. 2092-2094. 6 vols. "The Chronicles of Narnia: The Pattering of a Fantastic World." Folio Bound Views. CD-ROM. Folio Corp. 1994. NIV Collegiate Devotional Bible. Gran Rapids: Zondervan Publishing House., 1998. Fisher, Margery. Who's Who In Children's Books. New York: Holt, 1998. Lewis, C[live] S[taples]. The Lion, the Witch and the Wardrobe. New York: HarperTrophy, 1950. ---. Prince Caspian. New York: HarperTrophy, 1951. Lindskoog, Kathryn, Ann. " Lewis, C. S.". World Literature Criticism. Ed. James P. Draper. Vol. 4. Detriot: Gale. 1992. 2082-2084. 6 vols. Lockerbie, Dr. Bruce. "LEWIS, C(live) S(taples)." Contemperary Literary Criticism. Ed. Carolyn Riley. Vol. 1. Detroit: Gale. 1973. 177. 21 vols. DCTalk., and Voice of the Martyrs. Jesus Freaks. Tulsa: Albury Publishing, 1999.

Student Loan Debt Should be Forgiven Essay examples -- Student Loan De

Does the amount of student loan debt have an effect on the economy? If so would forgiving student loan debt help lower the national debt or would it just increase it? According to Mary Claire Fischer, a writer for Kiplinger’s Personal Finance magazine, â€Å"two-thirds of students who receive bachelor’s degrees leave college with an average debt of twenty-six thousand dollars† (Fischer). This means that the average student debt has doubled since 2007 (Ross 24). The total student loan debt is $1.2 trillion with $1 trillion being from federal student loans (Denhart). This debt accounts for six percent of our nation’s $16.7 trillion debt (Denhart). Since student loan debt is such a big part of the national debt, if the student defaults on their loan then the United States tax payer has to carry the burden of the loan (Denhart). Students who are graduating with debt do have a couple of different options that they can choose from. There is a six month grace period after graduation to allow the student time to find a job and programs to try to help eliminate debt. â€Å"The Consumer Financial Protection Bureau estimates that one-fourth of the American workforce may be eligible for repayment or loan forgiveness programs† (Atteberry n.p.). The problem with these programs however, is that they are hard to get into and stick with. Some of these programs that are options for students may require that student to move to another city or even another country. This option would work well for someone who is able to move, but what about someone who cannot leave where they currently live. These graduates may not want to leave because of family for example. Another problem with these programs is that the student with loan debt must fully comp... ... Emily. â€Å"Student Loan Forgiveness: What you Don’t Know (but Should).† USA Today. 6 Dec. 2013. Web. 17 Feb. 2015. Denhart, Chris. â€Å"How the $1.2 Trillion College Debt Crisis is Crippling Students, Parents, and the Economy.† Forbes. 7 Aug. 2013. Web. 13 Mar. 2015. Fischer, Mary Claire. â€Å"Student Loan Forgiveness: What to Know.† MSN. 9 Oct. 2013. Web. 17 Feb. 2015 Morici, Peter. â€Å"Forgiving College Debt Won’t Help Students.† CNBC. 14 May 2013. Web. 24 Feb. 2015. Pisani, Joseph. â€Å"A Guide to Student Loan Forgiveness and Repayment Options.† Huffington Post. 26 Sept. 2013. Web. 21 Feb. 2015. Ross, Andrew. â€Å"Mortgaging the Future: Student Debt in the Age of Austerity.† New Labor Forum (Sage Publications Inc.) 22.1 (2013): 23-28. Academic Search Complete. Web. 13 Mar. 2015 Webly, Kayla. â€Å"Is Forgiving Student Loan Debt a Good Idea?.† TIME. 20 Apr. 2012. Web. 17 Feb. 2015.

Climate change system

What is Climate Change?The clime is a complex and dynamic system. Throughout the Earth ‘s being, it has changed many times in response to natural procedures. However within the last 50 old ages, the composing of the planetary ambiance has significantly altered. The bulk of scientists now believe this recent clime alteration can be attributed to human activities. Since the industrial revolution, nursery gas degrees in the ambiance have considerably risen bring forthing an enhanced nursery consequence ( UKCIP 2005 ) . The nursery consequence is a natural procedure ; where a per centum of the thermal infrared radiation emitted by Earth is absorbed by a bed of natural nursery gases which reduces the chilling consequence of the Earth ( Met Office 2009 ) . It is widely accepted that, human activity has led to an addition in the concentration of these nursery gases in the ambiance, doing an enhanced nursery consequence. The increased temperatures produced, as a consequence of greater infrared opacity, are referred to as planetary heating. Current grounds of planetary warming comes from increasing ocean temperatures, lifting sea degrees, runing polar ice caps and decreasing snow screen in the Northern Hemisphere ( IPCC 2007 ) . Climate alteration projections suggest that these will go on to take topographic point and that there will be additions in the frequence and strength of utmost conditions events, such as drouths, inundations and tropical storms. Within the last hundred old ages, the planetary mean temperature of the Earth ‘s surface has risen, with 11 of the warmest old ages on record happening during the past 12 old ages ( IPCC 2007 ) . If the planetary heating continues at the present rate, it is predicted that mean planetary temperatures could lift by up to six grades Celsius by the terminal of this century ( DECC 2009b ) .Carbon DioxideThe chief nursery gas responsible for anthropogenetic ( human-made ) clime alteration is carbon dioxide, accounting for about 85 per cent of entire United Kingdom Ã¢â‚¬Ë œs nursery gas emanations ( Defra 2008 ) . The United Kingdom entirely emits about 555 million metric tons of C dioxide per twelvemonth. The largest known part of C dioxide emanations comes from the combustion of fossil fuels ; coal, oil and gas. The burning of fossil fuels has provided the chief energy beginning for all industries since the industrial revolution. Even with current raising fuel monetary values, it is still considered to be an economical method of bring forthing big measures of energy. The C dioxide is released as a bi-product into the ambiance, when the C nowadays in the dodo fuel reacts with O in the air, as the dodo fuel Burnss. The industrial sector bring forthing largest volume of C dioxide emanations is the energy supply sector. Three quarters of the United Kingdom ‘s electricity comes from coal and gas ( DECC 2009b ) . The largest manufacturer of electric within the United Kingdom is DRAX coal fired power station. It generates about 7 % of the United Kingdom ‘s electricity supply, with its operation bring forthing about 23 million metric tons of C dioxide each twelvemonth.Government TargetsThe Governments worldwide have appreciated the demand to cut down nursery gas emanations to forestall farther anthropogenetic clime alteration. The United Kingdom has a figure of aims, both international and domestic, for cut downing nursery gas emanations. The Climate Change Act became jurisprudence on 26 November 2008. The Act sets out the passage program for the United Kingdom to go a low-carbon economic system ( DECC 2009b ) . It gives curates the powers to present new steps necessary to accomplish the nursery gas decrease marks. Under the Climate Change Act the Government is lawfully required to cut emanations by 80 % of the 1990 degree by 2050 ( DECC 2009a ) . In order to accomplish this several intermediate C budgets have been set. Each C budget covers a five twelvemonth period and provides the maximal degrees of nursery gases that can be emitted into the ambiance during the period. Internationally, the United Kingdom has signed up to the Kyoto Protocol. The protocol commits 37 industrialised states, which have signed up, to undertake the issues of planetary heating and nursery gas emanations. The protocol sets lawfully binding marks for the decrease of nursery gases. The cardinal aim of the Kyoto Protocol is to cut down worldwide nursery gas emanations to 5.2 per centum below 1990 degrees, during the five-year period, between 2008 and 2012. The United Kingdom has agreed to cut down its nursery gas emanations by 12.5 per centum.Renewable Energy ProductionThe debut of Government marks creates a demand for alternate emanation free agencies of energy production. In add-on to undertaking clime alteration, the addition of renewable electric coevals reduces the United Kingdom ‘s dependance on non-renewable beginnings for future coevalss. This has led to a recent addition in the development of renewable energy engineerings. Renewable electricity coevals extracts energy from natural resources. It can be considered as emanation free power coevals. The most prevailing methods are solar energy, hydropower, geothermic energy, air current power, wave power, and tidal power. Presently, renewable energy coevals jointly provides about 5 % of the United Kingdom ‘s one-year electricity demand. The Government intends to bring forth around 30 % of our electricity from renewable beginnings by 2020.

Enlightenment Values In Europe Essay

The focal point of this paper is to evaluate and analyze the reasons behind the opposition to enlightenment values in Europe between the mid-18th and mid 20th centuries and who identify the section of the society that objected to progress, science, reason, liberty, happiness, etc. It can well be stated that the main aspect of this enlightenment was chiefly based on openness to religion, racism and civil rights along with freedom of thought process. These are all highly acclaimed values of today but back in mid-18th and mid 20th centuries, which are stated as Modern society, there were enough opposition in this context and this opposition was mainly economical. The idea of Modern Society is more of a concept than actuality. For this reason it is essential to define Modern Society. There are several notions regarding the concept of modern Society but most acceptable is the period dating from 1800s. Therefore, it is obvious that the era after 1800 (specifically after Industrial revolution) could be termed as Modern. However, when conceptualized, it can be stated there are several distinguishing features. It can well be stated that the industrial revolution brought the concept of modernism into existence during the mid-18th century. The most distinctive features of Modern society could be enumerated as Universality, development of Political thought, advent of technology and science, different inventions, approach towards Arts, Specified Cultures, distinctive warfare and industry. There are several social and economic factors that make the Modern society different from the Pre Modern Society. These social and economic factors are development of concepts like secularization, decontextualization, totalitarianism, mechanization, democratization, centralization, hierarchical organization, individualism, linear progression, homogenization, diversification, , hybridization, unification, industrial society, reductionism, , universalism, subjectivism, alienation, rationalization, and bureaucracy making the Modern society a complex and intricate civilization. Another distinctive feature of Modern society from its Pre modern counterpart is that during the modern era the advent of capital as a means of power came into existence. Previously this place was occupied by land in general. Alongside the advent of capital one of the most interesting feature that came into existence was the high volume of goods movement at a given state of time. In the Pre modern Society this phenomenon was unimaginable and Modern society only made it possible with help of capital and industrialization. (Kar, 2006) Yet another interesting feature of the Modern society is the availability of information. This became more easily available due to development of roads and other transportation and similar communication systems that made information abundant. Formerly, the areas that were separated by geographical barriers were broken down after the Pre modern Society and thus people became more aware of things happening around them. However, it should be taken into account that one of the most distinguishable aspects of modern society is its attitude towards sexuality and marriage. Given the many problems that are associated with marriage, it is not so surprising that many young people in Modern societies- which, to a great extent, now values individual fulfillment over traditions – have become disillusioned with the institution of marriage. This has resulted in the surging of non-traditional social structures. This could be termed as an extended approach of freedom of sexuality that flourished in the latter stages as one of the aspect of the civil right movements. This was predominantly an economy related factor as the voting rights of women and human rights of colored population were fallout of payment equality and right of work. All these factors instigated a complete openness to a number of aspects that was not only seen as immoral during the earlier period but also deem as sacrilege. It is obvious a section of the society was not in favor of the changes that were going around. The problem with these traditionalists was more economical than anything else. The lack of devotion towards the concept of God certainly displease the church as lesser interest in religion resulted into lesser amount of revenue and lower power in the sociopolitical perspective. The medieval period had the church at the center of all political and social structure and it gained huge authority over every aspect of life. Industrialization and economic independence certainly constricted the power and jurisdiction of the aspects of church and religion and thus made the religious authorities extremely unhappy about the proceedings. It was no surprise that the church openly opposed the progression of the European society. It was during this time slavery was banned first in United Kingdom and then the abolition was practiced all over Europe. This also was subjected to protests from certain part of the society, particularly from the commercial agricultural product manufacturers. These were the chief population that supported slavery in the different colonies of the Asia, Africa and Latin America under the imperialist banners of countries like UK, Germany, Spain, Portugal and France. Abolition of slavery was a huge attack on their profit margin and no wonder they protested with social and political influence and sometimes with financial and brute forces. (Lamb, 2004) The concept of civil rights developed as a logical fallout of these aspects. People were becoming aware of their position in the society through better mode of education and communication systems. The general mass was able to see the misgivings of the upper classes towards the rest of the population and identified the problem parts of the system and thus started to look for solution. The next step was rights for further participation into political arena and manifestation of political rights. Labor unrest and labor movement became a regular feature of the 19th century Europe and particularly in UK. These were movements that influenced the economical stability of the patricians of the society and hardly any of them was willing to part with their profit margin with the labors without a fight. Thus opposition in this case too was evident. It could also be stated that all the development of the era started from the openness of the thought process. The ultimate result was the combined force of religion and patricians worked overtime to resist this improvement of human dignity but eventually failed. King, 2006) In conclusion it can well be said that the driving force of history is predominantly economy and it is the different aspects and approach towards economy that give rise to conflicts and revolutions. It was true during the time of the crusades and it certainly relevant to the reasons behind the opposition to enlightenment values in Europe between the mid-18th and mid 20th centuries and objection of certain parts of the society against the aspects of progress, science, reason, l iberty and happiness.